Phytochemical analysis of the ethanolic Jasmine flower extract of Jasminum sambac (L.) Ait. ââ?¬Å?G. Duke of Tuscanyââ?¬Â revealed\r\nthe mixtures of coumarins, cardiac glycosides, essential oils, flavonoids, phenolics, saponins, and steroids. However, alkaloids,\r\nanthraquinones, and tannins were not detected. By intravenous injection at a single dose of 0.5 mL/mouse (15 mg) of the flower\r\nextract, no systemic biological toxicity demonstrated in ICR mice was observed. In Wistar rats, the LD50 of the extract was higher\r\nthan 5,000 mg/kg BW by oral administration. Vasodilatation effect of the 95% ethanolic extract on isolated aortic rats was also\r\ninvestigated. Compared with the control group, the Jasmine flowers extract in 0.05% DMSO clearly reduced tonus of isolated\r\nendothelium thoracic aortic rings preconstricted with phenylephrine (10-6 M), as a dose-dependent manner. Nevertheless, this\r\npharmacological effect disappeared after the preincubation of the rings with atropine (10-6 M) or with N?-nitro-L-arginine\r\n(10-4 M). These are possibly due to the actions of the active components on the vessel muscarinic receptors or by causing the\r\nrelease of nitric oxide.
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